Effects of Different Dosage of Epidural Droperidol on PONV in Patients with Postoperative Patient-controlled Epidural Analgesia with Tramadol and Bupivacaine.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /> Abstract:Objective To compare the effects and side effects of postoperative patient-controlled epidural analgesia(PCEA) with tramadol and bupivacaine mixture with different dosage of droperidol. Methods 120 ASAⅠ~Ⅱ patients underwent lower abdominal or lower limb surgeries were randomly divided into four PCEA groups. It contained 0, 2.5, 5, and 10mgof droperidol in 100ml mixture of 0.075%Bupivacain and 0.5%tremadol respectively in group1, 2, 3 and 4. VAS and scores of nausea, vomiting and sedation were evaluated during the first 24 h and 48 h after PCEA. Results There were no signifficant diffrences among four gorups on VAPs, D/D and consump. Conclusion Lower dosage of droperidol(2.5~5 mg/100 ml) with tramadol and bupivacaine mixture is superior for PCEA, nausea and vomiting are diminishing without changeover in quality of analgesia and sedation. High dosage of droperidol(10 mg/100 ml) with tramadol and bupivacaine mixture for PCEA provides a poor quality in diminishing nausea and vomiting and presents a deeper sedation than lower dosage droperidol group. ing the first 24 h after PCEA(P<0.05). Group 1 had a statistical difference on vomiting score compared to group 2 and group 3 (P<0.05). By statistical test, group 4 had deeper sedation scores than the other groups after PCEA (P<0.05) Key words: Droperidol,dosage; Mixture; Tramadol,bupivacaine; Patient-controlled epidural analgesia; PONV 病人自控硬膜外镇痛(PCEA)的效果确实,但存在一定副作用。以曲马多PCEA为例,在术后镇痛的同时也常出现恶心呕吐副作用。本研究拟在曲马多PCEA镇痛液中加入不同剂量氟哌利多,观察其对抗曲马多PCEA术后镇痛时恶心呕吐副作用的效应及是否同时增强镇痛效果,探索适宜的氟哌利多配伍剂量。今报告如下。 |